During your next ILLINOISouth adventure, consider staying in Columbia! In the shadow of St. Louis' Gateway Arch on the banks of the mighty Mississippi River, you'll find a quiet suburban community. The Hampton Inn by Hilton in Columbia is conveniently located adjacent to I-255, less than 15 miles from downtown St. Louis and minutes from southern St. Louis County. Discover Columbia's small-town Midwestern charm when you stay at the Hampton Inn Columbia hotel.